Search | Engineering

订阅投稿

首页工程期刊工程焦点工程成就工程前沿关于我们 English

资源类型

期刊论文 143

年份

2023 8

2022 11

2021 8

2020 14

2019 20

2018 3

2017 11

2016 5

2015 5

2014 11

2013 5

2012 4

2011 14

2010 1

2009 2

2008 3

2007 5

2006 2

2005 1

2004 1

展开︾

关键词

中药 10

中医 3

人才培养 3

公共卫生 3

COVID-19 2

SARS-CoV-2 2

中医史 2

中医药 2

临床医学 2

代谢组学 2

医学教育 2

发展战略 2

大健康 2

有效性 2

质量控制 2

鼠疫 2

2型糖尿病 1

一次性技术 1

万病归宗 1

展开︾

检索范围：

排序：展示方式：

Individualized medicine, health medicine, and constitutional theory in Chinese medicine

null

《医学前沿（英文）》 2012年第6卷第1期页码 1-7 doi: 10.1007/s11684-012-0173-y

摘要：

The patterns of modern science and changes in the medical model can result in the transformation of the current state of individualized and health medicines into being the primary trend in medical development. Chinese and Western medical systems are dissimilar in terms of value orientations, thinking style, and research directions because of their different historical and cultural backgrounds. Individualized treatment in modern medicine is mainly established based on individual genome information and the differences in mononucleotide polymorphi-sms. However, such treatment method is expensive, creates an uncertain genetic marker, and leads to different result interpretations, among other problems. The Chinese constitutional theory developed in the 1970s expresses the principle behind Chinese health medicine and individual treatment and provides the corresponding methods. The Chinese constitutional theory divides the constitution of the Chinese population into nine categories based on established classification criteria. It promotes the study of the relationship of each constitution to diseases and Chinese medicine preparation toward adjusting the constitution and preventing diseases. The theory also provides methods and tools for individualized treatment. Constitution identification shows the direction and provides the core technology for the evaluation of the health status. By combining the developments in modern biotechnology, new diagnostic techniques and treatment models of constitution-differentiation, disease-differentiation, and syndrome-differentiation can be established for the development of individualized Chinese medicine treatment and health medicine for the international medical community.

关键词： individualized medicine health medicine constitutional theory in Chinese medicine

HTML PDF 收藏

Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

null

《医学前沿（英文）》 2013年第7卷第2期页码 157-171 doi: 10.1007/s11684-013-0272-4

摘要：

Non-small-cell lung cancer (NSCLC) is the most common cause of premature death among the malignant diseases worldwide. The current staging criteria do not fully capture the complexity of this disease. Molecular biology techniques, particularly gene expression microarrays, proteomics, and next-generation sequencing, have recently been developed to facilitate effectively its molecular classification. The underlying etiology, pathogenesis, therapeutics, and prognosis of NSCLC based on an improved molecular classification scheme may promote individualized treatment and improve clinical outcomes. This review focuses on the molecular classification of NSCLC based on gene expression microarray technology reported during the past decade, as well as their applications for improving the diagnosis, staging and treatment of NSCLC, including the discovery of prognostic markers or potential therapeutic targets. We highlight some of the recent studies that may refine the identification of NSCLC subtypes using novel techniques such as epigenetics, proteomics, or deep sequencing.

关键词： non-small-cell lung cancer molecular typing individualized medicine molecular-targeted therapy gene expression profiling

HTML PDF 收藏

Thinking and practice of accelerating transformation of traditional Chinese medicine from experiencemedicine to evidence-based medicine

Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou

《医学前沿（英文）》 2011年第5卷第2期页码 163-170 doi: 10.1007/s11684-011-0143-9

摘要： The gradual development of Chinese medicine is based on constant accumulation and summary of experience in clinical practice, but without the benefit of undergoing the experimental medicine stage. Although Chinese medicine has formed a systematic and unique theory system through thousands of years, with the development of evidence-based medicine, the bondage of the research methods of experience medicine to Chinese medicine is appearing. The rapid transition and transformation from experience medicine to evidence-based medicine have become important content in the development of Chinese medicine. According to the features of Chinese medicine, we propose the research idea of “taking two ways simultaneously,” which is the study both in the ideal condition and in the real world. Analyzing and constructing the theoretical basis and methodology of clinical research in the real world, and building the stage for research technique is key to the effective clinical research of Chinese medicine. Only by gradually maturing and completing the clinical research methods of the real world could we realize “taking two ways simultaneously” and complementing each other, continuously produce scientific and reliable evidence of Chinese medicine, as well as transform and develop Chinese medicine from experience medicine to evidence-based medicine.

关键词： Chinese medicine experience medicine evidence-based medicine real world

HTML PDF 收藏

Clinical research of traditional Chinese medicine in big data era

null

《医学前沿（英文）》 2014年第8卷第3期页码 321-327 doi: 10.1007/s11684-014-0370-y

摘要：

With the advent of big data era, our thinking, technology and methodology are being transformed. Data-intensive scientific discovery based on big data, named “The Fourth Paradigm,” has become a new paradigm of scientific research. Along with the development and application of the Internet information technology in the field of healthcare, individual health records, clinical data of diagnosis and treatment, and genomic data have been accumulated dramatically, which generates big data in medical field for clinical research and assessment. With the support of big data, the defects and weakness may be overcome in the methodology of the conventional clinical evaluation based on sampling. Our research target shifts from the “causality inference” to “correlativity analysis.” This not only facilitates the evaluation of individualized treatment, disease prediction, prevention and prognosis, but also is suitable for the practice of preventive healthcare and symptom pattern differentiation for treatment in terms of traditional Chinese medicine (TCM), and for the post-marketing evaluation of Chinese patent medicines. To conduct clinical studies involved in big data in TCM domain, top level design is needed and should be performed orderly. The fundamental construction and innovation studies should be strengthened in the sections of data platform creation, data analysis technology and big-data professionals fostering and training.

关键词： big data traditional Chinese medicine clinical evaluation evidence based medicine

HTML PDF 收藏

光照世界史坛的中医起源之谜

符友丰

《中国工程科学》 2006年第8卷第9期页码 1-12

摘要：

以疫病流行及其原型分析为线索，联系早期治法（如热熨、火灸、砭刺等）探讨了古代以腺鼠疫为代表的疫病流行与医学起源间的内在联系；以医源于疫的视野分析我国医史病史研究在出土文物、古文字和医学文献等方面丰富的信息资源与优势；分析解读疾病名实的古今变迁、比较中西医学及其在认识论与方法论上的差异，为审视我国传统医学在疫病防治方面的丰富经验与延至今日的独到成就与意义，疾病史研究成果与推广，实现古为今用，将为当今疫病防治的中西互补、中西医结合与比较提供宝贵的历史经验与借鉴。

关键词：世界医学史中医史医学起源鼠疫霍乱天花比较医学

HTML PDF 收藏

Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China

Jian Wang, Wen Zou

《医学前沿（英文）》 2011年第5卷第2期页码 123-126 doi: 10.1007/s11684-011-0124-z

摘要： Traditional Chinese medicine (TCM) has become widely used in the treatment of acquired immune deficiency syndrome (AIDS) in China in recent years. In this article, we summarize the recent major developments in human immunodeficiency virus/AIDS (HIV/AIDS) treatment with TCM. The use of TCM is associated with preventing or alleviating HIV-related symptoms, reducing treatment side effects, and improving the quality of life. The potential beneficial effects of TCM should be confirmed through extensive and rigorous trials.

关键词： HIV/AIDS traditional Chinese medicine

HTML PDF 收藏

Traditional Chinese medicine in the new century

Jianxiang Liu, Zhu Chen

《医学前沿（英文）》 2011年第5卷第2期页码 111-114 doi: 10.1007/s11684-011-0125-y

HTML PDF 收藏

Do not let precision medicine be kidnapped

null

《医学前沿（英文）》 2015年第9卷第4期页码 512-513 doi: 10.1007/s11684-015-0425-8

摘要：

Obama’s precision medicine initiative made the medical community boil over after the initiative’s release. Precision medicine has been advocated by the majority of scientists and doctors. However, some experts have questioned this concept. This article does not oppose precision medicine. However, the incentive of vigorously promoting precision medicine at present is a concern.

关键词： precision medicine personalized medicine genomics

HTML PDF 收藏

Holistic integrative medicine: toward a new era of medical advancement

null

《医学前沿（英文）》 2017年第11卷第1期页码 152-159 doi: 10.1007/s11684-017-0499-6

摘要：

Medicine has encountered unprecedented problems associated with changes in nature, society, and environment, as well as with new human quests for survival, longevity, and health. In the meantime, the development of medicine is facing challenges that resulted from the over-division and specialization of disciplines and the fragmentation of medical knowledge. To construct a new medical system that is more suitable for human health and disease treatment, holistic integrative medicine (HIM), which regards the human body as a holistic entity, organically integrates the most advanced knowledge and theories in each medical field and the most effective practices in various clinical specialties to revise and adjust on the basis of social, environmental, and psychological conditions. HIM is the inevitable and necessary direction for the future development of medicine. In this article, we illustrated the connotation of HIM, the differences between HIM and other medical conceptions, and the practice of HIM in recent years.

关键词： holistic integrative medicine precision medicine general practice medicine

HTML PDF 收藏

中医的渊源和对中医学发展的思考

王文奎,王峰,王岭

《中国工程科学》 2006年第8卷第4期页码 1-11

摘要：

传统的中医学源远流长，博大精深，疗效显著，由于种种历史原因，加之自身流派众多，传承艰难，流传至今，已不能满足现代社会的发展与要求。中医要发展，须走“医学衷中纳西”的与时俱进之路。中医自身要统一理论认识，统一辩证纲领，统一到“五脏阴阳”之中，以“三维守恒”指导辩证，要明确医学的目的，认识生命的本质和生命运动的机制；要宏观与微观相结合，整体与局部相统一，以唯象涵盖唯物，以辩证指导分析，以调为本，以平为期；要司岁备药，先法制病，对中药剂型进行改进，以适应社会发展的需要。

关键词：中医发展历程与现状衷中纳西中药剂型

HTML PDF 收藏

Multi-stage emergency medicine logistics system optimization based on survival probability

Ke WANG, Yixin LIANG, Lindu ZHAO

《工程管理前沿（英文）》 2017年第4卷第2期页码 221-228 doi: 10.15302/J-FEM-2017020

摘要： Using sudden cardiac deaths as an example and maximizing survival rate as the goal, this paper studies the influence of multi-stage medical logistics system optimization on the survival rate of sudden illness. A distribution model of survival is built, drone and ambulance arrival probability over time are discussed, a formula is proposed for maximum possible survival rate based on the probability of emergency medical logistics reaching the patient, and the results are analyzed using empirical data fitting distribution and numerical experiments performed with the model. The model is discussed as a reference point for management decision making by changing model parameters. Results show that compared to using current ambulance vehicles, ambulance drones delivering medical equipment for first aid on-site in emergencies can significantly increase survival rate, and the effect of collaborative multi-stage logistics optimization is better than that of any single stage logistics response optimization. Simulation results show that the medical rescue logistics service radius, speed, loading capacity and performance of ambulance drones impact the probability of survival, and there is an optimal service radius depending on the shape of probability distribution, which provides new information for management decisions.

关键词： emergency medicine logistics ambulance drone survival probability critical illness

HTML PDF 收藏

2020年度医药卫生前沿

医药卫生项目组

《全球工程前沿》 2020年第4卷第1期页码 174-199

HTML PDF 收藏

2022年度医药卫生前沿

医药卫生项目组

《全球工程前沿》 2022年第6卷第1期页码 202-240

HTML PDF 收藏

Heterogeneous length-of-stay modeling of post-acute care residents in the nursing home with competing discharge dispositions

《工程管理前沿（英文）》页码 577-591 doi: 10.1007/s42524-022-0203-7

摘要： Post-acute care (PAC) residents in nursing homes (NHs) are recently hospitalized patients with medically complex diagnoses, ranging from severe orthopedic injuries to cardiovascular diseases. A major role of NHs is to maximize restoration of PAC residents during their NH stays with desirable discharge outcomes, such as higher community discharge likelihood and lower re/hospitalization risk. Accurate prediction of the PAC residents’ length-of-stay (LOS) with multiple discharge dispositions (e.g., community discharge and re/hospitalization) will allow NH management groups to stratify NH residents based on their individualized risk in realizing personalized and resident-centered NH care delivery. Due to the highly heterogeneous health conditions of PAC residents and their multiple types of correlated discharge dispositions, developing an accurate prediction model becomes challenging. Existing predictive analytics methods, such as distribution-/regression-based methods and machine learning methods, either fail to incorporate varied individual characteristics comprehensively or ignore multiple discharge dispositions. In this work, a data-driven predictive analytics approach is considered to jointly predict the individualized re/hospitalization risk and community discharge likelihood over time in the presence of varied residents’ characteristics. A sampling algorithm is further developed to generate accurate predictive samples for a heterogeneous population of PAC residents in an NH and facilitate facility-level performance evaluation. A real case study using large-scale NH data is provided to demonstrate the superior prediction performance of the proposed work at individual and facility levels through comprehensive comparison with a large number of existing prediction methods as benchmarks. The developed analytics tools will allow NH management groups to identify the most at-risk residents by providing them with more proactive and focused care to improve resident outcomes.

关键词： nursing home predictive analytics individualized prediction competing risks health outcomes